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KMID : 0385019960120010117
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Korean Journal of Laboratory Animal Science
1996 Volume.12 No. 1 p.117 ~ p.121
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Teratological Studies of Ginkgo biloba Extract(EGb 761)in Rats
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이영순/Lee, Yong Soon
박재학/남정석/제정환/양재만/이석만/강병철/Part, Jae Hak/Nam, Jeong Seok/Che, Jeong Hwan/Yang, Jae Man/Lee, Sok Man/Kang, Byeong Cheol
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Abstract
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A study was performed using Sprague-Dawley rats to examine the teratological potential of Ginkgo biloba extract(EGb 761), which is a known strong platelet activating factor antagonist. Ginkgo biloba extract(EGb 761) was administered intravenously during the organogenesis period (day 6th to 16th of gestationl of rats at dose levels of 7.5, 15 and 30㎎/㎏/day. Ail pregnant females were sacrified on day 20 of gestation and teratological abnormalities of their fetuses were examined.
Significant difference of body weight change between control and treated groups during experimental periods was noted. There was no statistically significant difference of numbers of corpus lutes and implantations and rate of fetal death, absorption and pregnancy and of placental weighs between control and rats exposed to three different concentration ranges of Ginkgo biloba extract(EGb 761). No marked external, visceral and skeletal abnormalities related to Ginkgo biloba extract(EGb 761) were observed in the fetuses.
In conclusion, Ginkgo biloba eYtract(EBb 761) dose not show any effect on implantation or embryonic development when it was administered intravenously during the organogenesis period by dose level of 30㎎/㎏/day.
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